12/13/2023 0 Comments Chromium gtf dosage for diabetesThe safety of various oral chromium doses is discussed. The data on chromium surveyed below includes historical background of biological effects, as well as results of chromium supplementation on hypoglycemia, diabetes, serum cholesterol, serum dehydroepiandrosterone (DHEA), and calcium excretion. Along with the question of chromium dosage level, there is also the question of potential variation in absorption or utilization with different chromium compounds. While evidence for this concern is sparse, the question deserves to be examined along with potential benefits of higher chromium doses.Ĭhromium compounds (along with other higher-than-divalent minerals) are not readily absorbed. Questions have arisen as to whether chromium at higher dosages can cause DNA fragmentation (clastogenic effect), which is separate from any issue of biochemical toxicity. Chromium supplementation does result in tissue retention, especially in the kidney, although no pathogenic effect has been demonstrated despite considerable study.Ĭhromium, an essential nutrient for human life, has been used at dosages higher than the minimum nutritional level to offset problems of malabsorption or to pharmacologically influence the chemistry of blood sugar control in diabetics. There is evidence of hormonal effects of supplemental chromium besides the effect on insulin. Relative absorption of various chromium compounds is summarized and the mechanism of low molecular weight chromium binding substance (LMWCr) in up-regulating the insulin effect eight-fold is discussed. Serum glucose can be improved by chromium supplementation in both types 1 and 2 diabetes, and the effect appears dose dependent. The beneficial effects of chromium on serum glucose and lipids and insulin resistance occur even in the healthy. While studies have found DNA fragmentation (clastogenic effects) by chromium picolinate, anecdotal reports of high-dose chromium picolinate toxicity are few and ambiguous. Previous claims of mutagenic effects of chromium are of questionable relevance. The 350-fold difference between the acceptable daily intake and the calculated reference dose for humans of 70 mg per day seems without precedent with respect to other nutritional minerals. The data on the standards for chromium requirements and the safety of various chromium compounds and doses are reviewed.
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